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Herbs & Supplements

Sarsaparilla
Other Names: Khao Yen, Sarsa, Smilace, Smilax, Smilax aristolochiifolia, Smilax glabra, Smilax officinalis, Smilax regelii, Smilax sarsaparilla, Tufuling

References

Ageel AM, Mossa JS, al-Yahya MA, al-Said MS, Tariq M. Experimental studies on antirheumatic crude drugs used in Saudi traditional medicine. Drugs in Experimental Clinical Research. 1989;15(8):369-372.

Ban JY, Cho SO, Choi SH, et al. Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo. Journal of Pharmacological Science. 2008;106(1):68-77.

Ban JY, Cho SO, Koh SB, Song KS, Bae K, Seong YH. Protection of amyloid beta protein (25-35)-induced neurotoxicity by methanol extract of Smilacis chinae rhizome in cultured rat cortical neurons. Journal of Ethnopharmacology. 2006;106(2):230-237.

Ban JY, Jeon SY, Bae K, Song KS, Seong YH. Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid beta protein (25-35)-induced neurotoxicity through inhibition of cytosolic calcium elevation. Life Sciences. 2006;79(24):2251-2259.

Bucci LR. Selected herbals and human exercise performance. American Journal of Clinical Nutrition. 2000;72(suppl):624S-636S.

Caceres A, Lopez BR, Giron MA, Logemann H. Plants used in Guatemala for the treatment of dermatophytic infections. 1. Screening for antimycotic activity of 44 plant extracts. Journal of Ethnopharmacology. 1991;31(3):263-276.

Chu KT, Ng TB. Smilaxin, a novel protein with immunostimulatory, antiproliferative, and HIV-1-reverse transcriptase inhibitory activities from fresh Smilax glabra rhizomes. Biochemistry and Biophysics Research Communications. 2006;340(1):118-124.

Dattner AM. From medical herbalism to phytotherapy in dermatology: back to the future. Dermatological Therapy. 2003;16(2):106-113.

Fukunaga T, Miura T, Furata K, Kato A. Hypoglycemic effect of the rhizomes of Smilax glaba in normal and diabetic mice. Biological and Pharmaceutical Bulletin. 1997;20(1):44-46.

HealthNotes, Inc. Sarsaparilla. 2002. Available at: http://www.mycustompak.com/healthNotes/Herb/Sarsapa rilla.htm Accessed November 18, 2002.

Iddamaldeniya SS, Thabrew MI, Wickramasinghe SM, Ratnatunge N, Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. Journal of Carcinogenesis. 2006;5:11.

Iddamaldeniya SS, Wickramasinghe N, Thabrew I, Ratnatunge N, Thammitiyagodage MG. Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: a preliminary study. Journal of Carcinogenesis. 2003;2(1):6.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Jiang J, Xu Q. Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats. Journal of Ethnopharmacology. 2003;85(1):53-59.

Lee SE, Ju EM, Kim JH. Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root. Experimental Molecular Medicine. 2001;33(4):263-268.

Lee H, Lin JY. Antimutagenic activity of extracts from anticancer drugs in Chinese medicine. Mutation Research. 1988;204(2):229-234.

Li YL, Gan GP, Zhang HZ, et al. A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. Journal of Ethnopharmacology. 2007;113(1):115-124.

Man MQ, Shi Y, Man M, et al. Chinese herbal medicine (Tuhuai extract) exhibits topical anti-proliferative and anti- inflammatory activity in murine disease models. Experimental Dermatology. Epublished ahead of print. March 12, 2008.

Natural Medicines Comprehensive Database, Online Edition. Pharmacist's Letter/Prescriber's Letter. Stockton CA: Therapeutic Research Facility, 2006. Available at: http://www.pharmacistsletter.com/(S(ulqz3s45omt3ag5 5um4kj345))/home.aspx?li=1&st=1&cs=&s=ND.

< P>Ooi LS, Wong EY, Chiu LC, Sun SS, Ooi VE. Antiviral and anti-proliferative glycoproteins from the rhizome of Smilax glabra Roxb (Liliaceae). American Journal of Chinese Medicine. 2008;36(1):185-195.

Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: Stonesong Press; 1999.

Rafatullah S, Mossa JS, Ageel AM, Al-Yahya MA, Tariq M. Hepatoprotective and safety evaluation studies on sarsaparilla International Journal of Pharmacognosy. 1991;29(4):296-301.

Rhee JK, Woo KJ, Baek BK, Ahn BJ. Screening of the wormicidal Chinese raw drugs on Clonorchis sinensis. American Journal of Chinese Medicine. 1981;9(4):277-284.

Sa F, Gao JL, Fung KP, Zheng Y, Lee SM, Wang YT. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chemical and Biological Interactions. 2008;171(1):1-14.

Sautour M, Miyamoto T, Lacaille-Dubois MA. Steroidal saponins from Smilax medica and their antifungal activity. Journal of Natural Products. 2005;68(10):1489-1493.

Shao B, Guo H, Cui Y, Ye M, Han J, Guo D. Steroidal saponins from Smilax china and their anti-inflammatory activities. Phytochemistry. 2007;68(5):623-630.

Shu XS, Gao ZH, Yang XL. Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract. Journal of Ethnopharmacology. 2006;103(3):327-332.

Shu XS, Gao ZH, Yang XL. The anti-inflammation effects of Smilax china ethylacetate extract in rats and mice. [Article in Chinese] Zhongguo Zhong Yao Za Zhi. 2006;31(3):239-243.

Taylor L. Herbal Secrets of the Rainforest, 2nd edition. Roseville, California. Prima Publishing, Inc. 2002.

Vandenplas O, Depelchin S, Toussaint G, Delwiche JP, Weyer RV, Saint-Remy JM. Occupational asthma caused by sarsaparilla root dust. Journal of Allergy and Clinical Immunology. 1996;97(6):1416-1418.

Xu W, Liu J, Li C, Wu HZ, Liu YW. Kaempferol-7-O-beta-d-glucoside (KG) isolated from Smilax china L. rhizome induces G(2)/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Letters. Epublished ahead of print. March 13, 2008.

Last Revised April 18, 2008

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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